As we mark an important milestone—the Skoll Foundation’s first CEO transition—we believed it important to capture the aspirations, values, and ways of working that constitute the DNA of the Foundation launched by Jeff Skoll and led by Sally Osberg. “As much as I am overwhelmed by the scope and scale of the problem,” reflects Sally Osberg as she steps down after 17 years of leadership of the Skoll Foundation. “I’m heartened by the evidence of what’s possible.”